Does "Fight or Flight" Need Updating?

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Understanding user interactions in stereoscopic head-mounted displays

2022 Spring.Includes bibliographical references.Interacting in stereoscopic head mounted displays can be difficult. There are not yet clear standards for how interactions in these environments should be performed. In virtual reality there are a number of well designed interaction techniques; however, augmented reality interaction techniques still need to be improved before they can be easily used. This dissertation covers work done towards understanding how users navigate and interact with virtual environments that are displayed in stereoscopic head-mounted displays. With this understanding, existing techniques from virtual reality devices can be transferred to augmented reality where appropriate, and where that is not the case, new interaction techniques can be developed. This work begins by observing how participants interact with virtual content using gesture alone, speech alone, and the combination of gesture+speech during a basic object manipulation task in augmented reality. Later, a complex 3-dimensional data-exploration environment is developed and refined. That environment is capable of being used in both augmented reality (AR) and virtual reality (VR), either asynchronously or simultaneously. The process of iteratively designing that system and the design choices made during its implementation are provided for future researchers working on complex systems. This dissertation concludes with a comparison of user interactions and navigation in that complex environment when using either an augmented or virtual reality display. That comparison contributes new knowledge on how people perform object manipulations between the two devices. When viewing 3D visualizations, users will need to feel able to navigate the environment. Without careful attention to proper interaction technique design, people may struggle to use the developed system. These struggles may range from a system that is uncomfortable and not fit for long-term use, or they could be as major as causing new users to not being able to interact in these environments at all. Getting the interactions right for AR and VR environments is a step towards facilitating their widespread acceptance. This dissertation provides the groundwork needed to start designing interaction techniques around how people utilize their personal space, virtual space, body, tools, and feedback systems

The human fear-circuitry and fear-induced fainting in healthy individuals The paleolithic-threat hypothesis

The Paleolithic-Threat hypothesis reviewed here posits that habitual efferent fainting can be traced back to fear-induced allelic polymorphisms that were selected into some genomes of anatomically, mitochondrially, and neurally modern humans (Homo sapiens sapiens) in the Mid-Paleolithic because of the survival advantage they conferred during periods of inescapable threat. We posit that during Mid-Paleolithic warfare an encounter with “a stranger holding a sharp object” was consistently associated with threat to life. A heritable hard- wired or firm-wired (prepotentiated) predisposition to abruptly increase vagal tone and collapse flaccidly rather than freeze or attempt to flee or fight in response to an approaching sharp object, a minor injury, or the sight of blood, polymorphism for the hemodynamically “paradoxical” flaccid- immobility in response to these stimuli may have increased some non-combatants’ chances of survival. This is consistent with the unusual age and sex pattern of fear-induced fainting. The Paleolithic-Threat hypothesis also predicts a link to various hypo-androgenic states (e.g. low dehydroxyepiandrosterone-sulfate. We offer five predictions testable via epidemiological, clinical, and ethological/primatological methods. The Paleolithic-Threat hypothesis has implications for research in the aftermath of man-made disasters, such as terrorism against civilians, a traumatic event in which this hypothesis predicts epidemics of fear-induced faintin

First passage time of N excluded volume particles on a line

Motivated by recent single molecule studies of proteins sliding on a DNA molecule, we explore the targeting dynamics of N particles ("proteins") sliding diffusively along a line ("DNA") in search of their target site (specific target sequence). At lower particle densities, one observes an expected reduction of the mean first passage time proportional to 1/N**2, with corrections at higher concentrations. We explicitly take adsorption and desorption effects, to and from the DNA, into account. For this general case, we also consider finite size effects, when the continuum approximation based on the number density of particles, breaks down. Moreover, we address the first passage time problem of a tagged particle diffusing among other particles.Comment: 9 pages, REVTeX, 6 eps figure

Characterization of theThreshold for NAD(P)H:quinone Oxidoreductase Activity in Intact Sulforaphane-treated Pulmonary Arterial Endothelial Cells

Treatment of bovine pulmonary arterial endothelial cells in culture with the phase II enzyme inducer sulforaphane (5 μM, 24 h; sulf-treated) increased cell-lysate NAD(P)H:quinone oxidoreductase (NQO1) activity by 5.7 ± 0.6 (mean ± SEM)-fold, but intact-cell NQO1 activity by only 2.8 ± 0.1-fold compared to control cells. To evaluate the hypothesis that the threshold for sulforaphane-induced intact-cell NQO1 activity reflects a limitation in the capacity to supply NADPH at a sufficient rate to drive all the induced NQO1 to its maximum activity, total KOH-extractable pyridine nucleotides were measured in cells treated with duroquinone to stimulate maximal NQO1 activity. NQO1 activation increased NADP+ in control and sulf-treated cells, with the effect more pronounced in the sulf-treated cells, in which the NADPH was also decreased. Glucose-6-phosphate dehydrogenase (G-6-PDH) inhibition partially blocked NQO1 activity in control and sulf-treated cells, but G-6-PDH overexpression via transient transfection with the human cDNA alleviated neither the restriction on intact sulf-treated cell NQO1 activity nor the impact on the NADPH/NADP+ ratios. Intracellular ATP levels were not affected by NQO1 activation in control or sulf-treated cells. An increased dependence on extracellular glucose and a rightward shift in the Km for extracellular glucose were observed in NQO1-stimulated sulf-treated vs control cells. The data suggest that glucose transport in the sulf-treated cells may be insufficient to support the increased metabolic demand for pentose phosphate pathway-generated NADPH as an explanation for the NQO1 threshold

Carrier-controlled ferromagnetism in SrTiO3

Magnetotransport and superconducting properties are investigated for uniformly La-doped SrTiO3 films and GdTiO3/SrTiO3 heterostructures, respectively. GdTiO3/SrTiO3 interfaces exhibit a high-density two-dimensional electron gas on the SrTiO3-side of the interface, while for the SrTiO3 films carriers are provided by the dopant atoms. Both types of samples exhibit ferromagnetism at low temperatures, as evidenced by a hysteresis in the magnetoresistance. For the uniformly doped SrTiO3 films, the Curie temperature is found to increase with doping and to coexist with superconductivity for carrier concentrations on the high-density side of the superconducting dome. The Curie temperature of the GdTiO3/SrTiO3 heterostructures scales with the thickness of the SrTiO3 quantum well. The results are used to construct a stability diagram for the ferromagnetic and superconducting phases of SrTiO3.Comment: Revised version that is closer to the published version; Fig. 2 correcte

Gender differences in skin and core body temperature during exercise in a hot, humid environment.

Background. It is universally accepted that men and women regulate heat differently during exercise in hot, humid environments. Despite this common knowledge, little empirical data is available to explain how gender differences effect core/skin temperature changes. Further, the data that is available includes only limited measurement sites and/or time points. Methods. The purpose of this study was to measure the heat regulatory patterns for both men and women during 60-min of exercise in a hot, humid environment. Twenty aerobically fit subjects (10 men; 10 women) completed an acclimation session followed by a 60-min exercise protocol in an environmental chamber set at 39.9 ± 1.1 °C and 46.4 ± 4% relative humidity. Each exercise protocol consisted of four intervals of an 8-min walk (mean ± SD; men: 4.0 ± 0.3, women: 3.0 ± 0.2 mph) and 7-min light jog (men: 5.4 ± 0.5, women: 5.0 ± 0.3 mph). Subjects were confirmed to be euhydrated (urine specific gravity) prior to exercise and were encouraged to drink water to maintain hydration during exercise. Pre- and Post-exercise body weights did not differ, thus it appears hydration was maintained during exercise. Skin temperatures (iButton wireless loggers) were recorded every minute at seventeen sites (right and left: upper chest, mid-chest, abdomen, upper back, mid-back, lower back, upper arm, and lower arm, and back of the neck). In addition, core body temperature (rectal), rating of perceived exertion (RPE), and heart rate (wireless telemetry) were also recorded at the end of each interval of the protocol. Statistical analysis was carried out using a 2 (gender) x 60 (time) repeated measures ANOVA. Other variables were analyzed using a 2 (gender) x 8 (time) ANOVA with repeated measures on the 2nd factor. Any non-normally distributed data was log transformed. Significance was set at p\u3c0.05 and location of effects will be determined using individual t-tests with a Bonferroni correction for multiple comparisons. Results. Analysis revealed significantly higher skin temperatures in four locations on men compared to women: right upper back (p=0.048), right mid-back (p=0.001), right lower back (p=0.001), and left upper back (p\u3c0.001). Additionally, these changes were seen despite no significant differences between genders in core body temperature, RPE, and heart rate. This latter finding supports the conclusion that a similar degree of exercise, heat stress was applied to both men and women. Conclusions. We found gender differences at four different skin temperature locations. These changes might suggest that men retain more metabolic heat in various locations on the back when exercising in a hot, humid environment compared to women. Further research is needed to understand how these changes may affect post-exercise recovery return to baseline skin and core temperature values